APP Binding Tau Proteins Intracellular Pathways Explored
AI Art Image Prompt
Prompt
amloid前体蛋白(APP)的ectodomain能够与细胞外游离tau蛋白结合,通过触发APP的内吞,携带细胞外tau进入细胞内,完成tau蛋白的摄取。细胞外病理型tau蛋白,如磷酸化tau和tau寡聚体,也可以通过这一途径被摄取进入细胞。摄入的病理性tau蛋白进一步从溶酶体中逃逸,在细胞内引发tau蛋白磷酸化和聚集,导致细胞内的tau病理加重,最终造成突触损伤和细胞死亡。
AI Art Prompt Analyze
- Subject: The image depicts the interaction between the ectodomain of amyloid precursor protein (APP) and extracellular tau proteins, highlighting the process of endocytosis and intracellular uptake. Setting: The setting can be a cellular environment, with a focus on the cell membrane where the interaction between APP and tau proteins occurs. Background: The background may feature elements representing cellular structures like membranes, receptors, and vesicles, indicating the intracellular processes involved in tau protein uptake. Style/Coloring: The style could be scientific and informative, possibly resembling diagrams or illustrations found in cell biology textbooks. The coloring might be vibrant to emphasize key molecular components and interactions. Action: The main action involves the binding of APP to extracellular tau proteins, followed by endocytosis and intracellular trafficking of tau proteins within the cell. Items: Key items include amyloid precursor protein (APP), extracellular tau proteins, cell membrane, endosomes, lysosomes, and intracellular tau aggregates. Costume/Appearance: The molecular structures of APP and tau proteins could be represented with accuracy, possibly using schematic representations or simplified 3D models. Accessories: Accessories may include molecular labels or annotations to highlight specific regions of interest, such as binding domains or phosphorylation sites.